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Natural history and malignant potential of simple ovarian cysts in postmenopausal women: a systematic review and meta-analysis The most common reason for surgeries was that the participants refused to follow up and chose surgery, even when conservative observation was possible Learn More – Primary Sources: The malignancy rate (including borderline tumors) was approximately 1 in 10,000 Women at high risk for ovarian cancer (e.g., family history of ovarian cancer) may benefit from consultation and potentially surgery.The conclusions of this study are more likely generalizable to women at average risk.The incidence of simple ovarian cysts that became malignant was extremely low.For postmenopausal women, simple ovarian cysts mostly remained unchanged or disappeared during follow-up.The malignancy rate (including borderline tumors) was very low.44.02% of participants chose surgery vs conservative management.During conservative observation, most cysts remained unchanged, or were disappearing.

12 cohort studies | 1672 participants | 1513 ovarian cysts.

Bias, study quality and heterogeneity were assessed.

Exclusion: Complex cysts and a high suspicion of malignancy.

No ascites and/or other signs of carcinomatosis.

Postmenopausal women with simple ovarian cysts.

(Menopause, 2023) investigated the natural history and malignant potential of postmenopausal simple ovarian cysts

Postmenopausal simple ovarian cysts are common, and conservative treatment is usually an option.

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